Table of Contents

Malware Outbreak Response

This runbook covers Microsoft Defender-driven response to suspected malware activity affecting one or more endpoints.

Initial Triage

  • Confirm the alert source, severity, and affected endpoint count
  • Identify whether execution is active, blocked, or historical
  • Review device criticality and business impact before containment

Investigation Steps

  • Review process tree, file path, and execution lineage
  • Check whether the same indicator appears on other devices
  • Review user context, recent sign-ins, and adjacent alerts
  • Determine whether lateral movement or persistence is present

Containment Actions

  • Isolate affected endpoints when active execution or spread is suspected
  • Quarantine confirmed malicious files where supported
  • Escalate high-impact or business-critical device isolation decisions

Recovery Validation

  • Confirm malicious processes no longer execute
  • Confirm device health and telemetry return to expected state
  • Confirm reintroduction to network is approved and documented

Evidence to Capture

  • Device ID and hostname
  • Alert IDs and timestamps
  • File hashes and process lineage
  • Containment actions and approvers